All terms in TMBAGEB

Label Id Description
DNA methylation EFO_0022599 [The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.]
biomarker of aging TM_BIN BMONT_0000136
amyloid-beta polypeptide 40 CHEBI_64646 [A beta-amyloid that is a 40 amino acid polypeptide of sequence Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val.]
replicative senescence GO_0090399 [A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.]
cellular senescence GO_0090398 [A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.]
amyloid-beta polypeptide 42 CHEBI_64647 [A beta-amyloid that ia a 42 amino acid polypeptide of sequence Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala.]
regenerative capacity BMONT_0000149 [Regenerative capacity is a complex trait dependent on the ability to access high-fidelity morphogenetic programmes after injury. It is distributed unequally among species and, within individuals, among their tissues.]
leukocyte telomere length BMONT_0000136 [Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders.]
cardiorespiratory fitness BMONT_0000135 [Cardiorespiratory fitness (CRF) refers to the capacity of the circulatory and respiratory systems to supply oxygen to skeletal muscle mitochondria for energy production needed during physical activity.]
Thing Thing
ELOVL2 hypermethilation BMONT_0000150 [Hayflick limit, ELOVL2 hypermethylation refers to an increase in DNA methylation at the ELOVL2 gene, which has been consistently associated with aging. The ELOVL2 gene encodes an enzyme involved in the elongation of very long-chain fatty acids. It has emerged as one of the most reliable epigenetic biomarkers of aging.]
Hayflick limit BMONT_0000151 [The Hayflick limit refers to the discovery by Leonard Hayflick that normal human cells grown in culture can only divide a finite number of times before entering a state of senescence, where they cease to divide. It describes a limit on the process of cell division and is related to the concept of cellular senescence.]
creatinine clearance CMO_0000765 [The clearance rate of creatinine, that is, the volume of plasma that is cleared of creatinine by the kidneys per unit time. Creatinine clearance is calculated using the level of creatinine in a sample of urine, usually one collected over a period of 24 hours, the corresponding plasma creatinine level, and the volume of urine excreted. It is used as an approximation of the glomerular filtration rate (GFR).]
muscle measurement EFO_0004515 [A muscle mass measurement is the quantification of the mass of a muscle e.g. skeletal muscle for an individual.]
epigenetic clock BMONT_0000139 [Epigenetic clocks are mathematically derived age estimators that are based on combinations of methylation values that change with age at specific CpGs in the genome.]
GrimAge clock BMONT_0000145 [An epigenetic clock called DNA methylation GrimAge (DNAmGrimAge) was specifically designed to connect the relationship between “grim” events such as death and biological age and its derivation was based on smoking pack-years and multiple inflammatory proteins associated with mortality.]
mitotic clock BMONT_0000146
decline in stem cell function BMONT_0000147 [The decline in stem cell function is a well-established feature of the aging process and plays a crucial role in the overall degeneration of tissues and organs as we age. Stem cells are responsible for tissue regeneration, repair, and maintaining homeostasis in the body. As we age, the function of these stem cells diminishes, leading to impaired tissue repair, reduced regeneration capacity, and an increased risk of age-related diseases.]
stem cell quantity BMONT_0000148 [The decline in stem cell function is a well-established feature of the aging process and plays a crucial role in the overall degeneration of tissues and organs as we age. Stem cells are responsible for tissue regeneration, repair, and maintaining homeostasis in the body. As we age, the function of these stem cells diminishes, leading to impaired tissue repair, reduced regeneration capacity, and an increased risk of age-related diseases.]
hannum clock BMONT_0000141 [The Hannum Clock is one of the early and widely recognized epigenetic clocks designed to estimate biological age by analyzing DNA methylation patterns. It was developed by Dr. Gregory Hannum and his colleagues in 2013 and represents a key advancement in the field of aging research.]