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Horvath clock
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BMONT_0000142 |
[The Horvath Clock, developed by Dr. Steve Horvath in 2013, is a groundbreaking epigenetic clock that estimates biological age based on DNA methylation patterns. This clock is widely regarded as one of the most accurate and versatile tools for measuring biological aging across different tissues and cell types. The Horvath Clock uses the methylation levels at specific CpG sites (regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide) to estimate an individual’s biological age. Methylation at these sites tends to correlate strongly with chronological age, but it can also reveal biological age, reflecting an individual's health status and aging rate.] |
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microbiome
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EFO_0004982 |
[A collection or collectivity of microorganisms.] |
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phosphorylated tau
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ADO_0000091 |
[A protein that is phosphorylated through post-translational modification. Its accumulation reflects the formation of neurofibrillary tangles, synaptic impairment, and neuronal dysfunction.] |
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DNAm PhenoAge
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BMONT_0000143 |
[DNAm PhenoAge is an epigenetic clock that allows for an estimate of phenotypic age from a single array, obviating the need for multiple assays to measure the nine blood-based components of phenotypic age., https://pubmed.ncbi.nlm.nih.gov/31780646/] |
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total tau
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ADO_0000090 |
[A protein that is regarded as a general marker of neurodegeneration for evaluation in future population-based studies and represents the total tau concentration in a given sample.] |
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proteomic clock
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BMONT_0000140 |
[A proteomic aging clock is a biological tool that estimates an individual's biological age based on the levels of specific proteins in the body. These proteins serve as biomarkers of aging, reflecting underlying processes such as inflammation, metabolism, immune function, and cellular repair mechanisms., generated with ChatGPT version 4,0 on 19․08․24] |
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neuroimaging measurement
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EFO_0004346 |
[Non-invasive methods of visualizing and measuring the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities e.g. CT scan] |
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telomere length
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EFO_0004505 |
[A measurement of telomere length measures the number of TTAGGG repeats at the end of the chromosome. As cell division proceeds telomeres shorten, telomere length is measure of cellular aging.] |
